Stimuler la voie Nrf2

What does Cellular Stress do?
"Too many damaging free radicals — or too few protective antioxidants — can wreak havoc on cell membranes, mitochondria, and DNA, leading to tissue damage and a wide range of chronic diseases, including cancer, chronic fatigue, diabetes, arthritis, and heart disease.
These oxygen molecules, often called “free radicals” or “reactive oxygen species” (ROS), can react with and cause damage to cellular structures throughout the body. Particularly vulnerable to oxidative damage are cell membranes, DNA (genetic material), and mitochondria (where cells generate energy)—and damage to these vital areas often means that cells cannot function properly."

Nrf2 regulates genes involved in the production of enzymes against oxidation and détox.
Soon after Nrf2 was identified, a flurry of scientific discoveries began to show how Nrf2 also regulated genes involved in the production of a wide range of antioxidant enzymes (including SOD, glutathione, and catalase), and detoxification or ‘‘stress-response’’ genes. These protective pathways are involved in seemingly unrelated areas of health from immune function to tissue optimization to cognitive function – but they all share in common the Nrf2 “switch” that enables cells to protect themselves from both internal and external environmental challenges. In effect, Nrf2 activation enables our cells to make their own “medicines” to help us survive – and thrive – in stressful situations.

How to upregulate Nrf2 (How to trigger Nrf2 production)

Nrf2 upregulation in the cells using R-lipoic acid, polyphenols, and sulphur-based compounds from cruciferous vegetables and alliums. The Ayurvedic herb haritaki is beneficial, as are sulforaphane (broccoli seed extract), and allicin and diallyl disulfide (garlic). All of these upregulate Nrf2 and aid detoxification.

How does Nrf2 work?

When activated, Nrf2 turns on the production of specific antioxidants the body needs to fight cellular stress effectively. Certain phytochemicals (turmeric, ashwaghandha, bacopa, green tea, and milk thistle) synergistically activate Nrf2. Turning on Nrf2 creates a cascading effect that results in the production of several very powerful antioxidants. These antioxidants do a much better job at combating cellular stress than dietary, vitamin or phytochemical source individually. Several antioxidant enzymes, including superoxide dismutase (SOD), glutathione, and catalase are activated through the Nrf2 pathway. Many scientists believe that Nrf2 activation is the “future” of cellular protection and health promotion, this foundation of naturally activating Nrf2 to “solve” the problem of cellular stress is a fundamentally different way of restoring balance in the body.

The three pillars of detoxification

1. Alleviate your liver.
2. Cleanse and clear your GI tract of toxins.

Be sure to drink extra water to flush the toxins out. If overloaded, stop stimulation and follow a strict procedure under control (or advised) to capture serum toxins. You need more grip-molecules, not less.

NB: Remember, if you're detoxing and feeling really unwell, you need to clear more toxins out of your GI tract and blood.

When you do that, back off your Nrf2 upregulators, and instead take more GI binders (charcoal e.g.) and more liver and kidney supporting herbs. Drink a lot of water. When you're feeling clear again, restart the Nrf2 upregulators.

3. Glutathione optimization. Increase glutathione levels either by using precursors (such as N-acetylcysteine [NAC], or a liposomal glutathione formulation.

4. Nrf2 upregulation in the cells using R-lipoic acid, polyphenols (resveratrol & quercetin; EGCG from green tea; phenolic acids from rosemary), and sulfur-based compounds from cruciferous vegetables and alliums. The Ayurvedic herb haritaki is beneficial, as are sulforaphane (broccoli seed extract), and allicin and diallyl disulfide (garlic). All of these upregulate Nrf2 and aids detoxification.

All of these compounds are generally considered to be antioxidants too.  They may be classified this way either because they directly scavenge free radicals or they indirectly increase endogenous cellular antioxidant defenses, for example, via activation of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2) transcription factor pathway.