Calcification des artères

Vitamin K is required to inhibit calcium accumulation in the arteries
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A new publication by Schurgers et al., titled [Vous devez être inscrit et connecté pour voir ce lien] elucidates the pivotal importance of vitamin K in the activation of Matrix Gla Protein (MGP), the most potent inhibitor of vascular calcification known. 

Vitamin D exerts toxicity by inducing a deficiency of vitamin K.
According to [Vous devez être inscrit et connecté pour voir ce lien]:
"The only mechanism for arteries to protect themselves from calcification is via the vitamin K-dependent protein MGP. MPG is the most powerful inhibitor of soft tissue calcification presently known, but non-supplemented healthy adults are insufficient in vitamin K to a level that 30 percent of their MGP is synthesized in an inactive form. So, protection against cardiovascular calcification is only 70 percent in the young, healthy population, and this figure decreases at increasing age."

The Role of Vitamin K in Soft-Tissue Calcification
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Vitamin K–dependent proteins have been identified to be involved in regulating soft-tissue calcification. Osteocalcin, matrix Gla protein (MGP), and possibly Gla-rich protein are all inhibitors of soft-tissue calcification and need vitamin K–dependent carboxylation for activity.
(…)
MGP is synthesized by vascular smooth muscle cells and is the most important inhibitor of arterial mineralization currently known. Remarkably, the extrahepatic Gla proteins mentioned are only partly carboxylated / activated in the healthy adult population, suggesting vitamin K insufficiency. Because carboxylation of the most essential Gla proteins is localized in the liver and that of the less essential Gla proteins in the extrahepatic tissues, a transport system has evolved ensuring preferential distribution of dietary vitamin K to the liver when vitamin K is limiting. 

Vitamin K2 is the substance that makes the vitamin A- and vitamin D-dependent proteins come to life. While vitamins A and D act as signalling molecules, telling cells to make certain proteins, vitamin K2 activates these proteins by conferring upon them the physical ability to bind calcium. In some cases these proteins directly coordinate the movement or organization of calcium themselves; in other cases the calcium acts as a glue to hold the protein in a certain shape.33 In all such cases, the proteins are only functional once they have been activated by vitamin K.
Osteocalcin, for example, is a protein responsible for organizing the deposition of calcium and phosphorus salts in bones and teeth. Cells only produce this protein in the presence of both vitamins A and D;34 it will only accumulate in the extracellular matrix and facilitate the deposition of calcium salts, however, once it has been activated by vitamin K2.35 Vitamins A and D regulate the expression of matrix Gla protein (MGP),36,37 which is responsible for mineralizing bone and protecting the arteries from calcification; like osteocalcin, however, MGP can only fulfil its function once it has been activated by vitamin K2.33 While vitamins A and D contribute to growth by stimulating growth factors and promoting the absorption of minerals, vitamin K2 makes its own essential contribution to growth by preventing the premature calcification of the cartilaginous growth zones of bones.38
Source: [Vous devez être inscrit et connecté pour voir ce lien] Weston Price - February 14, 2008 by Christopher Masterjohn.

Mirzoune a écrit:

Bon, mais moi, avec toutes ces infos, je m'y perds un peu... Parce qu'il y a aussi la vitamine A et que ça non plus c'est pas simple. Faut pas se gourer dans les proportions! Et, pour moi, c'est là que ça coince!

Dan a écrit:Vit A 10.000 ui 1x par semaine d après ce que j ai pigé

Luc a écrit:

Dan a écrit:Vit A 10.000 ui 1x par semaine d après ce que j ai pigé

 
Ou en mangeant des abats, une fois par semaine, d'un jeune animal (toxines).
Foie de poulet, foie de morue, etc.

C’est bien que qqu’un tire le signal d’alarme et me demande de simplifier. Je vais le faire mais il y aura parfois  un trou dans la chaîne 

1° Il y a une interdépendance / synergie entre les vitamines liposolubles A D K.
2° La vitamine K active certaines protéines.
3° les vitamines A et D ne peuvent remplir certaines fonctions que s’il y a de la vitamine K2. On dit ainsi que la vitamine D3 est dépendante de la vitamine K2.