The English corner: Fix the gut

The English corner: Fix the gut – 7 steps to cure histamine intolerance


[Vous devez être inscrit et connecté pour voir ce lien]  

Excerpt (video of Chris Masterjohn, under-titled) (With benchmarks at the 7 stages)
1. Video 47’’: Support you own endogenous production of DAO,
DAO is supposed to clear off all the histamine from food.
DAO = de-amine oxidase = enzyme able to degrade produced histamine.
Be sure to get enough of vitamin C B6 (P5P) and coper.
2. Video 1.48”: Supplement with DAO enzyme: kidney, liver worst, kidney supplement (= DAO supplement)
3. Video 2.49”: Support your methylation.
4. Video 3.37”: Mast cell control.
Mind lack of Se and retinol (vit A).
Mind inflammation (see medical doctor to handle the problem). Some molecules are prohibited (histamine producer and liberator).
5. Video 4.27”: Histamine from your diet
Mind the most offended food: aged, fermented or preserved food.
Examples of food high in histamine: semi- and hard cheese, canned anchovies, smoked fish, deli meat, curry, mustard, soy sauce, yeast, avocado, banana, dried food, dried nuts, lemon, mandarin,  and pineapple.
NDLR: These are only some most common examples, of food containing histamine (H). Some food cause the release (R) of histamine when they don't really contain it.
If you eat these foods you can’t get rid of intolerance, you can’t get cured: you’re only managing the intolerance (the excessive reaction of mast cells).
After healing, you may reintroduce some banned foods and see how you tolerate a slight amount of them.
6. Video 5.55’’: Alcohol and other drugs
Alcohol and some drugs interfere with histamine clearance. A sweet spot of alcohol can be tolerated 3 times a week. Many medications are concerned. See listing. 
7. Video 6.48’’: Fix the gut.
If inflamed, there could be a poor production of DAO enzyme, a mast cell burning and a microbiome dysbiosis.

Main points in practice
1. Support you own endogenous production of DAO with useful nutrients. Be sure to get enough of vitamin C B6 (P5P) and coper.
Pay attention:
- Not a vitamin B complex. 50 mg B6 is OK. B6 must be co-enzymed (P5P), without additive preferably.
·      Swanson, P-5-P-pyridoxal-5-phosphate, 20 mg, 60 capsules. 3.51 € iherb.com, 0.18 €/gel.
=>Advised choice for dosage if neuronal pathology (hypersensitivity).  1x/d.
·      Thorne, Pyridoxal 5'-phosphate, 180 capsules. 33.8 mg. With dioxide Si. 47.28 € - 10% by iherb..com, 0.263 €/gel.
·      Nutrabio 100 mg, 60 capsules. 14.72 €, 0.25 €/ gel. My choice because without excipient. 1x/ every other day (every two days).
- Chelated Coper (bisglycinate coper 10-15 mg, twice a day if suffering from dysbiosis).
- Vitamin C must be identified with CAS N° 50-81-7 (or with Specific Optical Rotation, between +20.5°~+21.5°) (without HM => certificate). Otherwise it’s half not assimilated (rubbish). Mine comes from Scotland, organic source (not from China). Labelled acid ascorbic quali-c (nutrimuscle.com 125 gr 22.95 €). Surfine powdered vitamin so that it dimots well, without residue.
+ Magnesium bisglycinate (HSN powder or nutrixeal.com) (lack)
2. DAO enzyme. 1 000 000 units.
I take NaturDAO 10-15’ before meal 3x/d. Gradually stop treatment (amazon.fr)
I won’t eat liver more than once every 5 days. And from organic source or from poultry (young chicken).
 3. Support your methylation: For example with betaïne HCL (Now Food, with pepsin) or with TMG supplement (Now Food, TMG 1000 mg or 2x 500 mg). I take TMG (tri-mehyl-glycine) 2250 mg from Super Smart (with a 30 % discount). No need to be so high.
NDLR: Chris Masterjohn has recommended TMG when taking B3 (niacin).
What is the difference between betaine HCl and trimethylglycine?
Betaine HCl has an acidic taste whereas anhydrous TMG ("anhydrous betaine") tastes sweet with a metallic aftertaste and is usually produced from sugar beets (as is betaine hydrochloride). Both are active as methyl donors, as 'betaine' is retained in both forms.
4. Mast cell control
I take quercetin anhydride 500 mg (nutrixeal.com) once a day. With a meal because some fat is required. In cure. Or every other week (every two weeks).
Mind some foods:    
We should not only worry about foods that contain large quantity histamine (H3 in the PDF list), but also foods that release histamine (L3 in the PDF list, in French) (L stands for liberation). For example, tuna is classified H3 (high contribution), the orange fruit is L3 (leads to a high reaction of histamine release).
5. Histamine Diet
See PDF list.
Useful info (in French)
[Vous devez être inscrit et connecté pour voir ce lien]
=> How to deal with histamine intolerance + short list of food high in histamine.
L3 (power 3/3) (L stand for liberator => set free)
Walnut, lemon (lime), orange, grapefruit, wine and balsamic vinegar, alcohol, iodine. Other examples on this link (list of incompatibility for histamine, in French):
Noix, citron vert (lime), orange, pamplemousse, vinaigre de vin et balsamique, alcool, iode.
Autres exemples sur ce lien (Liste d’incompatibilité à l’histamine) :
[Vous devez être inscrit et connecté pour voir ce lien]
It is not because a food brings little histamine that he does not cause a release of histamine. So be careful not to be based only on a single info source. It is above all the accumulation that must be avoided, and be careful in more sensitive times, of course.
Traduction : Ce n’est pas parce qu’un aliment apporte peu d’histamine qu’il n’entraine pas une libération d’histamine. Donc, attention à ne pas se baser seulement sur une seule source d’info. C’est surtout le cumul qu’il faut éviter, et faire attention en période plus sensible, évidemment.
6. Alcohol and other drugs
Alcohol overburdens liver detox. There are many drugs with prohibited molecules.
See link. I made a copy in a docx in order to make a search easily. By the way, I made 2 mistakes: curcumine and high dose B1 (thiamine). + pineapple (L2) in crisis.
This group does extensive research on histamine and is quite reputable. They list Thiamine/B1 as being a liberator and DAO blocker with certain types of administration:
Link for Thiamin as histamin liberator and DAO inhibitor (not only thiamin)
[Vous devez être inscrit et connecté pour voir ce lien]   
[Vous devez être inscrit et connecté pour voir ce lien]   (PDF with reference on histamine active substance, in English)
Reference:
Sattler J, Hesterberg R, Lorenz W, Schmidt U, Crombach M, Stahlknecht CD.: "Inhibition of human and canine diamine oxidase by drugs used in an intensive care unit: relevance for clinical side effects?" Agents Actions. 1985 Apr;16(3-4):91-4.
[Vous devez être inscrit et connecté pour voir ce lien]
(Liste unverträglicher Medikamente (DAO-Hemmer))
*) Low histamine Diet Anit Tee factvsfitness.com (pdf with info in English)
*) Liste de compatibilité alimentaire – Histamine 
Triée par ordre alphabétique, avec catégories.
Communauté d'intérêts Suisse de l'intolérance à l'histamine (SIGHI) [Vous devez être inscrit et connecté pour voir ce lien] => rubrique téléchargement / Liste détaillée de la compatibilité des aliments de base (rubrique au centre, encadrée : Régime alimentaire pour éliminer l'histamine > Téléchargement).
NB: Info disponible en anglais / français / allemand 
Liste PDF en français
[Vous devez être inscrit et connecté pour voir ce lien]
7. Fix the gut
=> Dysbiosis – Probiotics? – Strengthen gut walls – Target diet if intolerant gut (in French)
[Vous devez être inscrit et connecté pour voir ce lien]
[Vous devez être inscrit et connecté pour voir ce lien]

CM a écrit:Support your methylation

What is methylation?
Very few people know it, even though it is the keystone of a multitude of vital actions within our body. It takes place constantly in all the cells of our body at a frantic pace (up to a billion times per second). Biochemically, it is an extremely simple process which consists of the transmission of a methyl group (a carbon atom linked to 3 hydrogen atoms, or CH3) from one molecule to another.
Figure: methylation of a molecule (CH3 is added)
[Vous devez être inscrit et connecté pour voir ce lien]

Definition
Methylation is a biochemical modification consisting in the addition of a methyl group (CH3) to a molecule, under enzymatic control (methyltransferase).
From a Functional Medicine perspective, it is extremely important because it is a basic biochemical process involved in a multitude of different functions.
The Nutritional Factors that Affect Methylation:
– Folate
– Vitamin B12
– SAMe
– Vitamin B6
– Glycine
[Vous devez être inscrit et connecté pour voir ce lien]

Source: [Vous devez être inscrit et connecté pour voir ce lien]
But this process (methylation), apparently simple, alone ensures a multitude of functions in the human body, such as the production and regulation of a large number of molecules including neurotransmitters and hormones in the brain, the detoxification of the body via the production of glutathione (which is none other than the most powerful antioxidant in the human body), the breakdown of histamine in the intestine, but also and above all, according to one of the great discoveries of recent years, it allows the modulation of the expression of certain genes in our DNA via epigenetic processes. Methylation is therefore essential for the maintenance, repair and manufacturing of our cells, intracellular communication, and more particularly, the inheritance of epigenetic information from a mother cell to daughter cells during cell division (which is the way cells reproduce). (1)
Note:

These nutrients are often too short for a correct methylation: Vit C B6 (P-5-P) Mg

+ Other nutrients for recycling high levels of homocysteine. (2)
See next post.
Edit: Not too much B6 if you suffer from "brain". Begin with 20 mg P-5-P and adapt the frequency with the reaction. More B6 is needed in presence of inflammation. If problem, stop and wait 2 days more. Then every other day. Cut the gel. (if too high) if required.

Interaction of oxalates with methyl donors
[Vous devez être inscrit et connecté pour voir ce lien]

If you like eating nuts, legumes, spinach, beets and drinking hot chocolate or tea / coffee (several cups), or eating few dairies, on a regular basis, then you get too much oxalate for your body to handle with.
How are oxalate stones formed?
Oxalate is a residue of metabolism and is normally excreted from the body after its formation. Although 50% of oxalate results from regular/ordinary metabolism, 10-15% of oxalate is derived from diet. (1) Once oxalate is formed, it normally combines with calcium to be excreted in the stool. When large amounts of unabsorbed fat are available (e.g. due to fat malabsorption), calcium binds preferentially to fat rather than oxalate. This leaves the oxalate available to be easily reabsorbed by the colon and ends up in the urinary tract. In conditions where fat malabsorption is present, oxalate in urine is elevated. It is therefore necessary to ensure that lipids are properly digested, either by temporarily reducing the quantity or by providing additional digestive enzymes. (3)
Most people are unaware of the problem.
Oxalates generate great biochemical chaos in the body (4), more than any other component (except mercury).
Problems linked to sulfur (and by extension histamine and salicylates) can be caused by a struggling metabolism, which is no longer able to process excess foods rich in oxalates. It is the entire metabolism (the liver via different systems linked to sulfation and methylation) and the deprivation of nutrients useful to intestinal bacteria, which are altered. For example, pyroxidine (B6) is depleted in this oxalate neutralization process. We need B6 in the process of exchanging an oxalate molecule with a sulfate molecule. B6 is necessary for the functioning of approximately 150 enzymes linked to approximately 60 genes that regulate neurotransmitters and liver detoxification as well as general metabolism. (5)
[Vous devez être inscrit et connecté pour voir ce lien] (in French, translator needed).
Excerpt:
Oxalates interfere with sulfate transport (via Sat1 transporter).
The main reason why oxalates are so toxic is that each molecule of oxalate that enters our body will induce a loss of a molecule of sulfate. Sulfate uses the same transporter to enter and leave the body.
The main idea with oxalate toxicity is that it causes problems in the liver and kidneys – our two most important detoxification organs. While high oxalate levels cause liver problems and loss of vitamin B6, it is in the kidneys that oxalate causes us to lose much of our precious sulfate. The kidney is a key player in sulfate-related issues because it is the organ responsible for keeping our sulfate levels in balance. As already stated, the kidney must exchange an oxalate molecule for a sulfate molecule via the Sat1 transporter, and when oxalates are high, this causes a loss of sulfate in the urine.
Note: Sulfate is required for SOD enzyme too.
The function of superoxide dismutase (SOD) is to scavenge free radicals to combat cellular aging and associated health disorders.

A Reduced Level of B6 Induced
As if this were not enough (the loss of sulfate), high levels of oxalate induce a significant loss of vitamin b6 (pyridoxine). Do we really need to be reminded how important B vitamins are to our health – how they activate genetic pathways, produce energy, improve detoxification and allow our cells to survive. Vitamin B6, aka pyridoxine, is a particularly important B vitamin. It has many roles in the body, particularly in the liver where it helps process amino acids to promote growth, repair and detoxification. (6) 
See next post for sources.

Sources and References
0. Methylation explained (in French). Commercial site for nutritional supplements
[Vous devez être inscrit et connecté pour voir ce lien]
1. Mary Flesher, Clinical Dietitian, Vancouver General Hospital.
[Vous devez être inscrit et connecté pour voir ce lien]
2. Recycling high levels of homocysteine
Oregonstate: => oregonstate.edu and high homocysteine
3. I use Enzymedica LipoGold when the meal is overloaded. Well-dosed in lipases. But weak in other types. Price is correct.
4. Ela Marmotte
5. For Ela Marmote we shouldn’t blindly supplement with B6, without having done an analysis test to establish that there is a deficit or a deficiency. You have to find a balance.
Taking B6 must be balanced, with a larger magnesium intake. Bisglycinate Mg (because preferably amino-chelated) or Mg citrate because the citrate prevents Ca crystals from solidifying, and therefore avoid an agglomeration in a firm manner, provided that you drank enough water little mineralized, and that you have a balanced acid-base food (otherwise, bone-Ca release via PTH).
6. The Down Side to High Oxalates – Problems with Sulfate, B6, Gut and Methylation.
March 21, 2016.                                           
[Vous devez être inscrit et connecté pour voir ce lien]
Video Link: Proposed Mechanism of Renal Oxalate Handling (See figure 4.2 – Pathway for oxalate removal and detoxification). [Vous devez être inscrit et connecté pour voir ce lien]
- Pathway for oxalate removal and detoxification
- The low sulfate, high oxalate phenotype
7. More sources on the given link (in French, translator needed except for the sources).
[Vous devez être inscrit et connecté pour voir ce lien]
8. Methylation, MTHFR and Thyroid Dysfunction. By Benjamin Lynch, ND.
[Vous devez être inscrit et connecté pour voir ce lien]
Since 1 in 2 people have some form of MTHFR defect, folic acid is not the best form of folate to use. Defectuosity depends much on your ethnicity. Chinese, Italian, Hispanics or Mexican ethnic groups have nearly a 50% likelihood of being heterozygous for the MTHFR C677T defect and 20% to 30% are homozygous. 'This means that nearly 1 in 2 of these individuals will have a MTHFR enzyme functioning at 65% and 1 in 4 will have a MTHFR enzyme functioning at only 30%.
In a nutshell, it’s very common.
9. High folic acid intake reduces natural killer cell cytotoxicity in aged mice. Sawaengsria H et al. DOI: 10.1016/j. jnutbio.2015.12.006.
[Vous devez être inscrit et connecté pour voir ce lien]
The presence of unmetabolized folic acid in the blood is associated with decreased natural killer cytotoxicity.
A high intake of folic acid might mask detection of vitamin B12 deficiency and lead to a deterioration of central nervous system function in the elderly (significantly faster rate of cognitive decline).